Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm.

ABSTRACT:

Background

The cytokine storm (CS) triggered by coronavirus disease 2019 (COVID-19) has caused serious harm to health of humanity and huge economic burden to the world, and there is a lack of effective methods to treat this complication.

Purpose

In this research, we used network pharmacology and molecular docking to reveal the interaction mechanism in the glycyrrhetinic acid (GA) for the treatment of CS, and validated the effect of GA intervention CS by experiments.

Study design

First, we screened corresponding target of GA and CS from online databases, and obtained the action target genes through the Venn diagram. Then, protein-protein interaction (PPI) network, Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment of the a

SUBMITTER: Li H 

PROVIDER: S-EPMC9098921 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature