Novel Triterpenoid Alkaloids With Their Potential Cytotoxic Activity From the Roots of Siraitia grosvenorii.

ABSTRACT: Four novel triterpenoid alkaloids, siragrosvenins A-D (1-4), and two new cucurbitane-type triterpenoids, siragrosvenins E-F (5, 6), together with eight known analogs (7-14), were isolated from the roots of Siraitia grosvenorii. Compounds 1-4 possessed a rare cucurbitane-type triterpenoid scaffold, featuring an extra pyrazine unit via the Strecker reaction in the cucurbitane framework. Compound 5 displayed a 6/6/6/5/6/5-fused polycyclic ring system, with an uncommon fused furan and pyran ring in the side chain. All the structures were characterized by extensive spectroscopic analysis, including HRESIMS, NMR, and X-ray crystallographic data. It is worth noting that the DP4⁺ analysis method was applied for the first time to de

SUBMITTER: Wang H 

PROVIDER: S-EPMC9099095 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature