Utility of the ¹³ C-pantoprazole breath test as a CYP2C19 phenotyping probe for children.

ABSTRACT: The ¹³ C-pantoprazole breath test (PAN-BT) is a safe, noninvasive, in vivo CYP2C19 phenotyping probe for adults. Our objective was to evaluate PAN-BT performance in children, with a focus on discriminating individuals who, according to guidelines from the Clinical Pharmacology Implementation Consortium (CPIC), would benefit from starting dose escalation versus reduction for proton pump inhibitors (PPIs). Children (n = 65, 6-17 years) genotyped for CYP2C19 variants *2, *3, *4, and *17 received a single oral dose of ¹³ C-pantoprazole. Plasma concentrations of pantoprazole and its metabolites, and changes in exhaled ¹³ CO₂ (termed delta-over-baseline or DOB), were measured 10 times over 8 h using high performance liquid chromatography with ultraviol

SUBMITTER: Feldman K 

PROVIDER: S-EPMC9099127 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature