Elevated Vulnerability of Chronic Leukemia Patients to COVID-19 Infection: A Systems Biology Approach

ABSTRACT:

Background

Emerging evidence has shown that SARS-CoV-2 may affect the circulatory system in addition to the human respiratory system. However, no study has indicated whether patients with leukemia have a greater likelihood of SARS-CoV-2 infection or have poor treatment outcomes.

Objective

The study aimed to demonstrate the relationship between essential blood proteins and the major SARS-CoV-2 proteins by network pharmacology bioinformatics analysis.

Methods

Bioinformatics analysis was used to establish eight differentially expressed gene hubs in leukemia through differential gene screening, protein–protein interaction network analysis, and gene enrichment analysis. Molecular docking analysis was also conducted to dock the two up-regulated proteins with the spike

SUBMITTER: Alsalman A 

PROVIDER: S-EPMC9099323 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature