Lutetium Lu 177 Vipivotide Tetraxetan: First Approval.

ABSTRACT: Lutetium Lu 177 vipivotide tetraxetan (PLUVICTO™, formerly known as ¹⁷⁷Lu-PSMA-617) is a radioligand therapeutic agent that is being developed by Advanced Accelerator Applications (a subsidiary of Novartis) for the treatment of prostate-specific membrane antigen (PSMA)-expressing metastatic prostate cancer. The active part of the radiopharmaceutical is lutetium-177, which is linked to a ligand that binds to prostate-specific membrane antigen (PSMA), a transmembrane enzyme overexpressed in primary and metastatic prostate cancers. Based on efficacy results from the phase 3 VISION trial, lutetium Lu 177 vipivotide tetraxetan was approved in the USA on 23 March 2022 for the treatment of adult patients with PSMA-positive metastatic castration-resistant prostate cancer (mCRPC) who hav

SUBMITTER: Keam SJ 

PROVIDER: S-EPMC9099330 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature