Dendritic Cells and Their Immunotherapeutic Potential for Treating Type 1 Diabetes.

ABSTRACT: Type 1 diabetes (T1D) results from the destruction of pancreatic beta cells through a process that is primarily mediated by T cells. Emerging evidence suggests that dendritic cells (DCs) play a crucial role in initiating and developing this debilitating disease. DCs are professional antigen-presenting cells with the ability to integrate signals arising from tissue infection or injury that present processed antigens from these sites to naïve T cells in secondary lymphoid organs, thereby triggering naïve T cells to differentiate and modulate adaptive immune responses. Recent advancements in our knowledge of the various subsets of DCs and their cellular structures and methods of orchestration over time have resulted in a better understanding of how the T cell response is shaped. DCs employ va

SUBMITTER: Khan FU 

PROVIDER: S-EPMC9099521 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature