Hypoxia as a Modulator of Inflammation and Immune Response in Cancer.

ABSTRACT: A clear association between hypoxia and cancer has heretofore been established; however, it has not been completely developed. In this sense, the understanding of the tumoral microenvironment is critical to dissect the complexity of cancer, including the reduction in oxygen distribution inside the tumoral mass, defined as tumoral hypoxia. Moreover, hypoxia not only influences the tumoral cells but also the surrounding cells, including those related to the inflammatory processes. In this review, we analyze the participation of HIF, NF-κB, and STAT signaling pathways as the main components that interconnect hypoxia and immune response and how they modulate tumoral growth. In addition, we closely examine the participation of the immune cells and how they are affected by hypoxia, the effects o

SUBMITTER: Castillo-Rodriguez RA 

PROVIDER: S-EPMC9099524 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature