Biomarkers Associated with Lymph Nodal Metastasis in Endometrioid Endometrial Carcinoma.

ABSTRACT:

Introduction

Lymph node metastasis is determinant in the prognosis and treatment of endometrioid endometrial cancer (EEC) but the risk-benefit balance of surgical lymph node staging remains controversial.

Objective

Describe the pathways associated with lymph node metastases in EEC detected by whole RNA sequencing.

Methods

RNA-sequencing was performed on a retrospective series of 30 non-metastatic EEC. N+ and N- patients were matched for tumoral size, tumoral grade and myometrial invasion.

Results

Twenty-eight EECs were analyzable (16 N+ and 12 N-). Bioinformatics Unsupervised analysis revealed three patterns of expression, enriched in N+, mix of N+/N- and enriched in N-, respectively. The cluster with only N+ patient overexpressed extra cellular matrix, epithel

SUBMITTER: Maire M 

PROVIDER: S-EPMC9099548 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature