Exploring Diverse Coagulation Factor XIII Subunit Expression Datasets: A Bioinformatic Analysis.

ABSTRACT: Coagulation factor XIII (FXIII) circulates in plasma as a pro-transglutaminase heterotetrameric complex (FXIIIA₂B₂), which upon activation by thrombin and calcium covalently crosslinks preformed fibrin polymers. The heterotetrameric complex is composed of a catalytic FXIIIA₂ subunit and a protective/regulatory FXIII-B₂ subunit coded by F13A1 and F13B genes, respectively. The catalytic FXIIIA₂ subunit is encoded by the F13A1 gene, expressed primarily in cells of mesenchymal origin, whereas the FXIIIB subunit encoded by the F13B gene is expressed and secreted from hepatocytes. The plasma FXIIIA₂ subunit, which earlier was believed to be secreted from cells of megakaryocytic lineage, is now understoo

SUBMITTER: Jamil MA 

PROVIDER: S-EPMC9099568 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature