Calprotectin and Imbalances between Acute-Phase Mediators Are Associated with Critical Illness in COVID-19.

ABSTRACT: The trajectory from moderate and severe COVID-19 into acute respiratory distress syndrome (ARDS) necessitating mechanical ventilation (MV) is a field of active research. We determined serum levels within 24 h of presentation of 20 different sets of mediators (calprotectin, pro- and anti-inflammatory cytokines, interferons) of patients with COVID-19 at different stages of severity (asymptomatic, moderate, severe and ARDS/MV). The primary endpoint was to define associations with critical illness, and the secondary endpoint was to identify the pathways associated with mortality. Results were validated in serial measurements of mediators among participants of the SAVE-MORE trial. Levels of the proinflammatory interleukin (IL)-8, IL-18, matrix metalloproteinase-9, platelet-derived growth factor

SUBMITTER: Kassianidis G 

PROVIDER: S-EPMC9099708 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature