Corneal Confocal Microscopy Features and Tear Molecular Profile in Study Participants with Discordance between Ocular Surface Disease Clinical Signs and Discomfort.

ABSTRACT: Various ocular surface conditions such as dry eye disease can present with severe discomfort and pain. However, it is clinically challenging to establish etiology and prescribe correct treatment in patients who have a lot of discordance between symptoms and signs. To understand the basis of such discordance, we stratified subjects with ocular surface pain based on concordance between the severity of signs and symptoms and evaluated corneal structural features and tear molecular factors. All subjects underwent slit lamp examination, dry eye evaluation, and ocular surface disease index (OSDI) scoring. Subjects were stratified into group 1-without symptoms or clinical signs; group 2-without symptoms but with signs; group 3-with similar severity of symptoms and signs; and group 4-with symptom

SUBMITTER: D'Souza S 

PROVIDER: S-EPMC9099769 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature