Synthesis and Structural Study of Amidrazone Derived Pyrrole-2,5-Dione Derivatives: Potential Anti-Inflammatory Agents.

ABSTRACT: 1H-pyrrole-2,5-dione derivatives are known for their wide range of pharmacological properties, including anti-inflammatory and antimicrobial activities. This study aimed to synthesize new 3,4-dimethyl-1H-pyrrole-2,5-dione derivatives 2a-2f in the reaction of N³-substituted amidrazones with 2,3-dimethylmaleic anhydride and evaluate their structural and biological properties. Compounds 2a-2f were studied by the ¹H-¹³C NMR two-dimensional techniques (HMQC, HMBC) and single-crystal X-ray diffraction (derivatives 2a and 2d). The anti-inflammatory activity of compounds 2a-2f was examined by both an anti-proliferative study and a production study on the inhibition of pro-inflammatory cyto

SUBMITTER: Paprocka R 

PROVIDER: S-EPMC9099820 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature