One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles.

ABSTRACT: A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.

SUBMITTER: Aksenov NA 

PROVIDER: S-EPMC9099830 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature