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One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles.

ABSTRACT: A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.

SUBMITTER: Aksenov NA

PROVIDER: S-EPMC9099830 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature

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One-Pot Synthesis of (<i>E</i>)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles.

Aksenov Nicolai A NA Aksenov Alexander V AV Kurenkov Igor A IA Kirillov Nikita K NK Aksenov Dmitrii A DA Arutiunov Nikolai A NA Aksenova Daria S DS Rubin Michael M

Molecules (Basel, Switzerland) 20220428 9

A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of <i>ortho</i>-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction. ...[more]

PMID: 35566159

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