Improving Patients' Life Quality after Radiotherapy Treatment by Predicting Late Toxicities.

ABSTRACT: Personalized treatment and precision medicine have become the new standard of care in oncology and radiotherapy. Because treatment outcomes have considerably improved over the last few years, permanent side-effects are becoming an increasingly significant issue for cancer survivors. Five to ten percent of patients will develop severe late toxicity after radiotherapy. Identifying these patients before treatment start would allow for treatment adaptation to minimize definitive side effects that could impair their long-term quality of life. Over the last decades, several tests and biomarkers have been developed to identify these patients. However, out of these, only the Radiation-Induced Lymphocyte Apoptosis (RILA) assay has been prospectively validated in multi-center cohorts. This test, bas

SUBMITTER: Lapierre A 

PROVIDER: S-EPMC9099838 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature