Evaluation of Proton-Induced DNA Damage in 3D-Engineered Glioblastoma Microenvironments.

ABSTRACT: Glioblastoma (GBM) is a devastating cancer of the brain with an extremely poor prognosis. For this reason, besides clinical and preclinical studies, novel in vitro models for the assessment of cancer response to drugs and radiation are being developed. In such context, three-dimensional (3D)-engineered cellular microenvironments, compared to unrealistic two-dimensional (2D) monolayer cell culture, provide a model closer to the in vivo configuration. Concerning cancer treatment, while X-ray radiotherapy and chemotherapy remain the current standard, proton beam therapy is an appealing alternative as protons can be efficiently targeted to destroy cancer cells while sparing the surrounding healthy tissue. However, despite the treatment's compelling biological and medical rational

SUBMITTER: Akolawala Q 

PROVIDER: S-EPMC9100514 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature