Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties.

ABSTRACT: A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA-ctDNA and human serum albumin-HSA) and biological activities as potential anticancer agents on proliferation of A549 and CCD-18Co have been evaluated. The acridine-DNA complex 3b (-F) displayed the highest K_b value (K_b = 3.18 × 10³ M^-1). The HSA-derivatives interactions were studied by fluorescence quenching spectra. This method was used for the calculation of characteristic binding parameters. In the presence of warfarin, the binding constant values were found to decrease (K_SV = 2.26 M^-1, K_b = 2.54 M^-1), suggesting

SUBMITTER: Vilkova M 

PROVIDER: S-EPMC9100673 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature