Predictive modeling of spread in adult-onset isolated dystonia: Key properties and effect of tremor inclusion.

ABSTRACT:

Background and purpose

Several clinical and demographic factors relate to anatomic spread of adult-onset isolated dystonia, but a predictive model is still lacking. The aims of this study were: (i) to develop and validate a predictive model of anatomic spread of adult-onset isolated dystonia; and (ii) to evaluate whether presence of tremor associated with dystonia influences model predictions of spread.

Methods

Adult-onset isolated dystonia participants with focal onset from the Dystonia Coalition Natural History Project database were included. We developed two prediction models, one with dystonia as sole disease manifestation ("dystonia-only") and one accepting dystonia OR tremor in any body part as disease manifestations ("dystonia OR tremor"). Demographic and clinical pre

SUBMITTER: Wang M 

PROVIDER: S-EPMC9100858 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature