Recapitulation of Retinal Damage in Zebrafish Larvae Infected with Zika Virus.

ABSTRACT: Zebrafish are increasingly being utilized as a model to investigate infectious diseases and to advance the understanding of pathogen-host interactions. Here, we take advantage of the zebrafish to recapitulate congenital ZIKV infection and, for the first time, demonstrate that it can be used to model infection and reinfection and monitor anti-viral and inflammatory immune responses, as well as brain growth and eye abnormalities during embryonic development. By injecting a Brazilian strain of ZIKV into the yolk sac of one-cell stage embryos, we confirmed that, after 72 h, ZIKV successfully infected larvae, and the physical condition of the virus-infected hosts included gross morphological changes in surviving embryos (84%), with a reduction in larval head size and retinal damage characterize

SUBMITTER: Maleski ALA 

PROVIDER: S-EPMC9100881 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature