Molecular Characteristics of T Cell-Mediated Tumor Killing in Hepatocellular Carcinoma.

ABSTRACT:

Background

Although checkpoint blockade is a promising approach for the treatment of hepatocellular carcinoma (HCC), subsets of patients expected to show a response have not been established. As T cell-mediated tumor killing (TTK) is the fundamental principle of immune checkpoint inhibitor therapy, we established subtypes based on genes related to the sensitivity to TKK and evaluated their prognostic value for HCC immunotherapies.

Methods

Genes regulating the sensitivity of tumor cells to T cell-mediated killing (referred to as GSTTKs) showing differential expression in HCC and correlations with prognosis were identified by high-throughput screening assays. Unsupervised clustering was applied to classify patients with HCC into subtypes based on the GSTTKs. The tumor microenv

SUBMITTER: Hong WF 

PROVIDER: S-EPMC9100886 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature