Molecular Profiles of Advanced Urological Cancers in the PERMED-01 Precision Medicine Clinical Trial.

ABSTRACT:

Introduction

The prognosis of advanced urological cancers (AUC) remains unfavorable, and few data are available regarding precision medicine.

Methods

the PERMED-01 prospective clinical trial assessed the impact of molecular profiling in adults with refractory advanced solid cancer, in terms of number of patients with tumor actionable genetic alterations (AGA), feasibility, description of molecular alterations, treatment, and clinical outcome. We present here those results in the 64 patients enrolled with AUC. DNA extracted from a new tumor biopsy was profiled in real-time (targeted NGS, whole-genome array-comparative genomic hybridization), and the results were discussed during a weekly molecular tumor board meeting.

Results

a complete molecular profile was obtained i

SUBMITTER: Billon E 

PROVIDER: S-EPMC9100924 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature