Transcriptome-Wide Analysis of RNA N⁶-Methyladenosine Modification in Adriamycin-Resistant Acute Myeloid Leukemia Cells.

ABSTRACT: Acute myeloid leukemia (AML) is one of the most aggressive hematopoietic malignancies. Patients still suffer from refractory/relapsed disease after anthracycline-based therapy, which leads to a poor prognosis. N⁶-Methyladenosine (m⁶A) is the most abundant post-transcriptional modification in eukaryotes, the imbalance of which is reported to be associated with various pathological processes, including drug resistance. However, the relationship between m⁶A modification and drug resistance has not been well defined in AML. In this study, we analyzed the sequencing data of HL60 and its Adriamycin-resistant cell line HL60/ADR. We found a total of 40,550 m⁶A-methylated peaks, representing 15,640 genes in HL60, and 38,834 m⁶A-methylated peaks

SUBMITTER: Fang S 

PROVIDER: S-EPMC9100953 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature