Astrocytes Derived from Familial and Sporadic Alzheimer's Disease iPSCs Show Altered Calcium Signaling and Respond Differently to Misfolded Protein Tau.

ABSTRACT: Astrocytes regulate important functions in the brain, and their dysregulation has been linked to the etiology of neurodegenerative diseases, such as Alzheimer's disease (AD). The role of astroglia in human AD remains enigmatic, owing to the limitations of animal models, which, while recreating some pathological aspects of the disease, do not fully mirror its course. In addition, the recognition of major structural and functional differences between human and mouse astrocytes has also prompted research into human glial cells. In the current study, astrocytes were generated using human iPSCs from patients with sporadic Alzheimer's disease (sAD), familial Alzheimer's disease (fAD) and non-demented controls (NDC). All clones gained astrocyte-specific morphological and proteomic characteristics

SUBMITTER: Brezovakova V 

PROVIDER: S-EPMC9101114 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature