Cholic Acid-Based Antimicrobial Peptide Mimics as Antibacterial Agents.

ABSTRACT: There is a significant and urgent need for the development of novel antibacterial agents to tackle the increasing incidence of antibiotic resistance. Cholic acid-based small molecular antimicrobial peptide mimics are reported as potential new leads to treat bacterial infection. Here, we describe the design, synthesis and biological evaluation of cholic acid-based small molecular antimicrobial peptide mimics. The synthesis of cholic acid analogues involves the attachment of a hydrophobic moiety at the carboxyl terminal of the cholic acid scaffold, followed by the installation of one to three amino acid residues on the hydroxyl groups present on the cholic acid scaffold. Structure-activity relationship studies suggest that the tryptophan moiety is important for high antibacterial activity. M

SUBMITTER: Wu J 

PROVIDER: S-EPMC9101178 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature