A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression.

ABSTRACT: This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation.

SUBMITTER: Cohen-Armon M 

PROVIDER: S-EPMC9101275 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature