A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression.
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ABSTRACT:
SUBMITTER: Cohen-Armon M
PROVIDER: S-EPMC9101275 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Publications
A Long-Lasting PARP1-Activation Mediates Signal-Induced Gene Expression.
Cells 20220507 9
This overview presents recent evidence for a long-lasting PARP1 activation by a variety of signal transduction mechanisms, mediating signal-induced gene expression and chromatin remodeling. This mode of PARP1 activation has been reported in a variety of cell types, under physiological conditions. In this mechanism, PARP1 is not transiently activated by binding to DNA breaks. Moreover, damaged DNA interfered with this long-lasting PARP1 activation. ...[more]
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