Confining Fluorescent Probes in Nanochannels to Construct Reusable Nanosensors for Ion Current and Fluorescence Dual Gating.

ABSTRACT: Here, we confined fluorescent probes to solid nanochannels to construct nanosensors, which not only significantly improved the reusability of the molecular probes, but also achieved ion current and fluorescence dual gating for more reliable detection. The combination of optical and electrical modalities can provide comprehensive spatiotemporal information that can be used to elucidate the sensing mechanism within the nanochannel. As a proof-of-concept experiment, fluorescein isothiocyanate (FITC)-hydrazine (N₂H₄) was selected to modify nanochannels for the effective detection of Hg²⁺. Based on spirolactam opening tactics, the system synergistically alters the surface charge and fluorescence intensity in response to Hg²⁺, establishing a dual open

SUBMITTER: Zhang D 

PROVIDER: S-EPMC9101493 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature