Body Mass Index and the Risk of Atrial Fibrillation: A Mendelian Randomization Study.

ABSTRACT: Although observational studies have shown positive associations between body mass index (BMI) and the risk of atrial fibrillation (AF), the causal relationship is still uncertain owing to the susceptibility to confounding and reverse causation. This study aimed to examine the potential causality of BMI on AF by conducting a two-sample Mendelian randomization (TSMR) study.

Methods

The independent genetic variants associated with BMI (n = 303) at the genome-wide significant level were derived as instrumental variables (IV) from the Genetic Investigation of Anthropometric Traits (GIANT) consortium consisting of 681,275 individuals of European ancestry. We then derived the outcome data from a GWAS meta-analysis comprised of 60,620 cases and 970,216 controls of European ancestry.

SUBMITTER: Ma M 

PROVIDER: S-EPMC9101688 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature