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Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with closo-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters.

ABSTRACT: A series of novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to Bacillus cereus ATCC 10702 and are not active against Gram-negative microorganisms and Candida albicans at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide synthesized from the tetrahydropyran derivative of cobalt bis(dicarbollide) exhibited activity against Gram-positive microorganisms: Staphylococcus aureus ATCC 29213, Enterococcus faecalis ATCC 29212 and the clinical isolate MRSA 17, that surpassed curcumin by 2-4 times.

SUBMITTER: Druzina AA 

PROVIDER: S-EPMC9101702 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature

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Synthesis and Antibacterial Activity Studies of the Conjugates of Curcumin with <i>closo</i>-Dodecaborate and Cobalt Bis(Dicarbollide) Boron Clusters.

Druzina Anna A AA   Grammatikova Natalia E NE   Zhidkova Olga B OB   Nekrasova Natalia A NA   Dudarova Nadezhda V NV   Kosenko Irina D ID   Grin Mikhail A MA   Bregadze Vladimir I VI  

Molecules (Basel, Switzerland) 20220503 9

A series of novel conjugates of cobalt bis(dicarbollide) and <i>closo</i>-dodecaborate with curcumin were synthesized by copper(I)-catalyzed azide-alkyne cycloaddition. These conjugates were tested for antibacterial activity. It was shown that all derivatives are active when exposed to <i>Bacillus cereus</i> ATCC 10702 and are not active against Gram-negative microorganisms and <i>Candida albicans</i> at the maximum studied concentration of 1000 mg/L. The conjugate of alkynyl-curcumin with azide  ...[more]

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