Comparison of BMIPP-SPECT/CT to ¹⁸FDG-PET/CT for Imaging Brown or Browning Fat in a Preclinical Model.

ABSTRACT: Obesity is a leading cause of preventable death and morbidity. To elucidate the mechanisms connecting metabolically active brown adipose tissue (BAT) and metabolic health may provide insights into methods of treatment for obesity-related conditions. ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸FDG-PET/CT) is traditionally used to image human BAT activity. However, the primary energy source of BAT is derived from intracellular fatty acids and not glucose. Beta-methyl-p-iodophenylpentadecanoic acid (BMIPP) is a fatty acid analogue amenable to in vivo imaging by single photon emission computed tomography/CT (SPECT/CT) when radiolabeled with iodine isotopes. In this study, we compare the use of ¹⁸FDG-PET/CT and ¹²⁵I-BMIP

SUBMITTER: Frankl JA 

PROVIDER: S-EPMC9101718 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature