Wild Egyptian medicinal plants show in vitro and in vivo cytotoxicity and antimalarial activities.

ABSTRACT:

Background

Medicinal plants have been successfully used as an alternative source of drugs for the treatment of microbial diseases. Finding a novel treatment for malaria is still challenging, and various extracts from different wild desert plants have been reported to have multiple medicinal uses for human public health, this study evaluated the antimalarial efficacy of several Egyptian plant extracts.

Methods

We assessed the cytotoxic potential of 13 plant extracts and their abilities to inhibit the in vitro growth of Plasmodium falciparum (3D7), and to treat infection with non-lethal Plasmodium yoelii 17XNL in an in vivo malaria model in BALB/c mice.

Results

In vitro screening identified four promising candidates, Trichodesma africanum, Artemisia judaica, Cleome dros

SUBMITTER: Abdou AM 

PROVIDER: S-EPMC9101831 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature