Capsule-Targeting Depolymerases Derived from Acinetobacter baumannii Prophage Regions.

ABSTRACT: In this study, several different depolymerases encoded in the prophage regions of Acinetobacter baumannii genomes have been bioinformatically predicted and recombinantly produced. The identified depolymerases possessed multi-domain structures and were identical or closely homologous to various proteins encoded in other A. baumannii genomes. This means that prophage-derived depolymerases are widespread, and different bacterial genomes can be the source of proteins with polysaccharide-degrading activities. For two depolymerases, the specificity to capsular polysaccharides (CPSs) of A. baumannii belonging to K1 and K92 capsular types (K types) was determined. The data obtained showed that the prophage-derived depolymerases were glycosidases that cleaved the A. baumanni

SUBMITTER: Drobiazko AY 

PROVIDER: S-EPMC9102105 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature