Ontology highlight
ABSTRACT:
SUBMITTER: Peltanova B
PROVIDER: S-EPMC9102192 | biostudies-literature | 2022 May
REPOSITORIES: biostudies-literature
Peltanová Barbora B Holcová Polanská Hana H Raudenská Martina M Balvan Jan J Navrátil Jiří J Vičar Tomáš T Gumulec Jaromír J Čechová Barbora B Kräter Martin M Guck Jochen J Kalfeřt David D Grega Marek M Plzák Jan J Betka Jan J Masařík Michal M
Cancers 20220503 9
Head and neck squamous cell carcinomas (HNSCC) belong among severe and highly complex malignant diseases showing a high level of heterogeneity and consequently also a variance in therapeutic response, regardless of clinical stage. Our study implies that the progression of HNSCC may be supported by cancer-associated fibroblasts (CAFs) in the tumour microenvironment (TME) and the heterogeneity of this disease may lie in the level of cooperation between CAFs and epithelial cancer cells, as communic ...[more]