Data-Driven Mathematical Model of Apoptosis Regulation in Memory Plasma Cells.

ABSTRACT: Memory plasma cells constitutively produce copious amounts of antibodies, imposing a critical risk factor for autoimmune disease. We previously found that plasma cell survival requires secreted factors such as APRIL and direct contact to stromal cells, which act in concert to activate NF-κB- and PI3K-dependent signaling pathways to prevent cell death. However, the regulatory properties of the underlying biochemical network are confounded by the complexity of potential interaction and cross-regulation pathways. Here, based on flow-cytometric quantification of key signaling proteins in the presence or absence of the survival signals APRIL and contact to the stromal cell line ST2, we generated a quantitative model of plasma cell survival. Our model emphasizes the non-redundant nature of the t

SUBMITTER: Burt P 

PROVIDER: S-EPMC9102437 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature