Targeting Epigenetic Modifiers of Tumor Plasticity and Cancer Stem Cell Behavior.

ABSTRACT: Tumor heterogeneity poses one of the greatest challenges to a successful treatment of cancer. Tumor cell populations consist of different subpopulations that have distinct phenotypic and genotypic profiles. Such variability poses a challenge in successfully targeting all tumor subpopulations at the same time. Relapse after treatment has been previously explained using the cancer stem cell model and the clonal evolution model. Cancer stem cells are an important subpopulation of tumor cells that regulate tumor plasticity and determine therapeutic resistance. Tumor plasticity is controlled by genetic and epigenetic changes of crucial genes involved in cancer cell survival, growth and metastasis. Targeting epigenetic modulators associated with cancer stem cell survival can unlock a promising t

SUBMITTER: Kumar VE 

PROVIDER: S-EPMC9102449 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature