Characterization of Triterpene Saponin Glycyrrhizin Transport by Glycyrrhiza glabra.

ABSTRACT: Glycyrrhizin (GL), a triterpene compound produced by Glycyrrhiza species, is a crucial pharmacologically active component of crude drugs. In contrast to the biosynthesis of GL in plants, little is known about GL transport and accumulation in plants. The transport mechanism of GL was characterized using cultured cells of Glycyrrhiza glabra. Cultured cells of G. glabra efficiently incorporated exogenously supplied GL. Proton pump inhibitors, such as probenecid and niflumic acid, as well as a protonophore (carbonylcyanide m-chlorophenylhydrazone), markedly inhibited GL uptake by cultured cells, whereas vanadate exhibited a moderate inhibition. Furthermore, GL transport by G. glabra tonoplast vesicles is dependent not on a H⁺-electrochemical gradie

SUBMITTER: Kato K 

PROVIDER: S-EPMC9102456 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature