Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex.

ABSTRACT: At glutamatergic synapses, astrocytes respond to the neurotransmitter glutamate with intracellular Ca²⁺ elevations and the release of gliotransmitters that modulate synaptic transmission. While the functional interactions between neurons and astrocytes have been intensively studied at glutamatergic synapses, the role of astrocytes at GABAergic synapses has been less investigated. In the present study, we combine optogenetics with 2-photon Ca²⁺ imaging experiments and patch-clamp recording techniques to investigate the signaling between Somatostatin (SST)-releasing GABAergic interneurons and astrocytes in brain slice preparations from the visual cortex (VCx). We found that an intense stimulation of SST interneurons evokes Ca²⁺ elevations in astrocytes that f

SUBMITTER: Henriques VJ 

PROVIDER: S-EPMC9102536 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature