Integrated bioinformatics analysis of potential biomarkers for pancreatic cancer.

ABSTRACT:

Background

Pancreatic cancer, particularly pancreatic ductal adenocarcinoma (PDA), is an aggressive malignancy associated with a low 5-year survival rate. Poor outcomes associated with PDA are attributable to late detection and inoperability. Most patients with PDA are diagnosed with locally advanced and metastatic disease. Such cases are primarily treated with chemotherapy and radiotherapy. Because of the lack of effective molecular targets, early diagnosis and successful therapies are limited. The purpose of this study was to screen key candidate genes for PDA using a bioinformatic approach and to research their potential functional, pathway mechanisms associated with PDA progression. It may help to understand the role of associated genes in the development and progression of PDA

SUBMITTER: Shi H 

PROVIDER: S-EPMC9102654 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature