A Comparative Study of the Role of Formins in Drosophila Embryonic Dorsal Closure.

ABSTRACT: Dorsal closure is a late embryogenesis process required to seal the epidermal hole on the dorsal side of the Drosophila embryo. This process involves the coordination of several forces generated in the epidermal cell layer and in the amnioserosa cells, covering the hole. Ultimately, these forces arise due to cytoskeletal rearrangements that induce changes in cell shape and result in tissue movement. While a number of cytoskeleton regulatory proteins have already been linked to dorsal closure, here we expand this list by demonstrating that four of the six Drosophila formin type actin assembly factors are needed to bring about the proper fusion of the epithelia. An analysis of the morphological and dynamic properties of dorsal closure in formin mutants revealed a differential c

SUBMITTER: Toth K 

PROVIDER: S-EPMC9102720 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature