RAGE is a potential biomarker implicated in immune infiltrates and cellular senescence in lung adenocarcinoma.

ABSTRACT:

Background

Receptor for Advanced Glycation End-products (RAGE) is an oncogene abnormally expressed in various cancers. However, the clinical value of RAGE and the biological role of RAGE in lung cancer have not been fully investigated.

Methods

We compared the RAGE expression using several public databases. The relationship between RAGE expression and clinicopathological variables was assessed. The R software package was used to carry out enrichment analyses of RAGE co-expression and gene set enrichment analysis (GSEA). Additionally, we used the TIMER database to assess the association between immune infiltration and RAGE expression. The correlation between RAGE expression and senescence biomarkers in lung adenocarcinoma was analyzed using the TCGA database.

Results

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SUBMITTER: Lin Z 

PROVIDER: S-EPMC9102728 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature