Polycomb contraction differentially regulates terminal human hematopoietic differentiation programs.

ABSTRACT:

Background

Lifelong production of the many types of mature blood cells from less differentiated progenitors is a hierarchically ordered process that spans multiple cell divisions. The nature and timing of the molecular events required to integrate the environmental signals, transcription factor activity, epigenetic modifications, and changes in gene expression involved are thus complex and still poorly understood. To address this gap, we generated comprehensive reference epigenomes of 8 phenotypically defined subsets of normal human cord blood.

Results

We describe a striking contraction of H3K27me3 density in differentiated myelo-erythroid cells that resembles a punctate pattern previously ascribed to pluripotent embryonic stem cells. Phenotypically distinct progenitor cell

SUBMITTER: Lorzadeh A 

PROVIDER: S-EPMC9102747 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature