System-level investigation of anti-obesity effects and the potential pathways of Cordyceps militaris in ovariectomized rats.

ABSTRACT:

Background

Cordyceps species have been used as tonics to enhance energy, stamina, and libido in traditional Asian medicine for more than 1600 years, indicating their potential for improving reproductive hormone disorders and energy metabolic diseases. Among Cordyceps, Cordyceps militaris has been reported to prevent metabolic syndromes including obesity and benefit the reproductive hormone system, suggesting that Cordyceps militaris can also regulate obesity induced by the menopause. We investigated the effectiveness of Cordyceps militaris extraction (CME) on menopausal obesity and its mechanisms.

Methods

We applied an approach combining in vivo, in vitro, and in silico methods. Ovariectomized rats were administrated CME, and their body weight, area of adipocytes, liver and

SUBMITTER: Jang D 

PROVIDER: S-EPMC9102749 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature