Mechanisms by Which Skeletal Muscle Myokines Ameliorate Insulin Resistance.

ABSTRACT: The skeletal muscle is the largest organ in the body and secretes circulating factors, including myokines, which are involved in various cellular signaling processes. Skeletal muscle is vital for metabolism and physiology and plays a crucial role in insulin-mediated glucose disposal. Myokines have autocrine, paracrine, and endocrine functions, serving as critical regulators of myogenic differentiation, fiber-type switching, and maintaining muscle mass. Myokines have profound effects on energy metabolism and inflammation, contributing to the pathophysiology of type 2 diabetes (T2D) and other metabolic diseases. Myokines have been shown to increase insulin sensitivity, thereby improving glucose disposal and regulating glucose and lipid metabolism. Many myokines have now been identified, and

SUBMITTER: Balakrishnan R 

PROVIDER: S-EPMC9102915 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature