Identification of a novel lipid metabolism-related gene signature within the tumour immune microenvironment for breast cancer.

ABSTRACT:

Background

Systemic factors can strongly affect how tumour cells behave, grow, and communicate with other cells in breast cancer. Lipid metabolic reprogramming is a systemic process that tumour cells undergo; however, the formation and dynamics of lipids associated with the tumour immune microenvironment (TIME) remain unclear. The investigation of the sophisticated bidirectional crosstalk of tumour cells with cancer metabolism, gene expression, and TIME could have the potential to identify novel biomarkers for diagnosis, prognosis, and immunotherapy. This study aimed to construct a prognostic signature to detect the bicrosstalk between the lipid metabolic system and the TIME of breast cancer.

Methods

To detect the expression of LRGs and execute GO/KEGG analysis, the R progra

SUBMITTER: Chang X 

PROVIDER: S-EPMC9103058 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature