Development and Validation of Benzophenone Derivatives in Packaged Cereal-Based Foods by Solid-Liquid Extraction and Ultrahigh-Performance Liquid Chromatography-Tandem Mass Spectrometry.

ABSTRACT: We established and validated a sensitive multi-residue analytical method for identifying benzophenone (BP) and nine BP derivatives (2,4-dihydroxybenzophenone [BP-1], 2,2',4,4'-tetrahydroxydroxybenzophenone, 2-hydroxy-4-methoxy benzophenone, 2,2'-dihydroxy 4-methoxy benzophenone, 2-hydroxybenzophenone [2-OHBP], 4-hydroxybenzophenone, 4-methylbenzophenone [4-MBP], methyl-2-benzoylbenzoate, and 4-benzoylbiphenyl). Solid-liquid extraction pretreatment and ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) were employed in an analysis of 85 packaged cereal-based food samples (25 pastry, 50 rice, and 10 noodle samples). The method had satisfactory linearity (R² ≥ 0.995), low limits of detection (pastry: 0.02-4.2 ng/g; rice and noodle: 0.02-2 ng/g), and

SUBMITTER: Huang YF 

PROVIDER: S-EPMC9103691 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature