The human antibody sequence space and structural design of the V, J regions, and CDRH3 with Rosetta.

ABSTRACT: The human adaptive immune response enables the targeting of epitopes on pathogens with high specificity. Infection with a pathogen induces somatic hyper-mutation and B-cell selection processes that govern the shape and diversity of the antibody sequence landscape. To date, even the largest immunome repertoires of adaptive immune receptors acquired by next-generation sequencing cannot fully capture the vast antibody sequence space of a single individual, which is estimated to be at least 10¹² potential sequences. Degeneracy of the genetic code means that the number of possible nucleotide triplets (64) is greater than the number of canonical amino acids (20), resulting in some amino acids being encoded by multiple triplets and different amino acids sharing the same nucleotide in 1

SUBMITTER: Schmitz S 

PROVIDER: S-EPMC9103704 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature