Fast, Ungapped Reads Mapping Using Squid.

ABSTRACT: Advances in Next Generation Sequencing technologies allow us to inspect and unlock the genome to a level of detail that was unimaginable only a few decades ago. Omics-based studies are casting a light on the patterns and determinants of disease conditions in populations, as well as on the influence of microbial communities on human health, just to name a few. Through increasing volumes of sequencing information, for example, it is possible to compare genomic features and analyze the modulation of the transcriptome under different environmental stimuli. Although protocols for NGS preparation are intended to leave little to no space for contamination of any kind, a noticeable fraction of sequencing reads still may not uniquely represent what was intended to be sequenced in the first place. I

SUBMITTER: Riccardi C 

PROVIDER: S-EPMC9103773 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature