Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis.

ABSTRACT: Neurodegenerative protein conformational diseases are characterized by the misfolding and aggregation of metastable proteins encoded within the host genome. The host is also home to thousands of proteins encoded within exogenous genomes harbored by bacteria, fungi, and viruses. Yet, their contributions to host protein-folding homeostasis, or proteostasis, remain elusive. Recent studies, including our previous work, suggest that bacterial products contribute to the toxic aggregation of endogenous host proteins. We refer to these products as bacteria-derived protein aggregates (BDPAs). Furthermore, antibiotics were recently associated with an increased risk for neurodegenerative diseases, including Parkinson's disease and amyotrophic lateral sclerosis-possibly by virtue of altering the compo

SUBMITTER: Walker AC 

PROVIDER: S-EPMC9103901 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature