NFAT Factors Are Dispensable for the Development but Are Critical for the Maintenance of Foxp3⁺ Regulatory T Cells.

ABSTRACT: The transcription factors of the nuclear factor of activated T cell (NFAT) family play a crucial role in multiple aspects of T cell function. It has recently been reported that NFATs play an important role in the suppressive function of CD4⁺CD25⁺Foxp3⁺ regulatory T (T_reg) cells. In this study, we have investigated the role of NFATs in the thymic development of T_reg cells in mice. We show that NFAT factors are dispensable for the development of Foxp3⁺ T_reg cells in the thymus but are critical for the maintenance of both the phenotype and survival of T_reg cells in the thymus as well as in peripheral lymphoid organs. Specifically, the homeostasis of CD4⁺CD25⁺Foxp3⁺ but not

SUBMITTER: Barahona de Brito C 

PROVIDER: S-EPMC9104130 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature