Phosphoproteomics Unravel HBV Triggered Rewiring of Host Phosphosignaling Events.

ABSTRACT: Hepatitis B virus (HBV) infection persists as a major global health problem despite the availability of HBV vaccines for disease prevention. However, vaccination rates remains low in some regions of the world, driving the need for novel strategies to minimise infections and prevent disease progression. Thus, understanding of perturbed molecular signaling events during early phases of HBV infection is required. Phosphosignaling is known to be involved in the HBV infection processes, yet systems-level changes in phosphosignaling pathways in the host during infection remain unclear. To this end, we performed phosphoproteome profiling on HBV-infected HepG2-NTCP cells. Our results showed that HBV infection drastically altered the host phosphoproteome and its associated proteins, including kinas

SUBMITTER: Lim Z 

PROVIDER: S-EPMC9104152 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature