Exosomal and Non-Exosomal MicroRNAs: New Kids on the Block for Cancer Therapy.

ABSTRACT: MicroRNAs have been projected as promising tools for diagnostic and prognostic purposes in cancer. More recently, they have been highlighted as RNA therapeutic targets for cancer therapy. Though miRs perform a generic function of post-transcriptional gene regulation, their utility in RNA therapeutics mostly relies on their biochemical nature and their assembly with other macromolecules. Release of extracellular miRs is broadly categorized into two different compositions, namely exosomal (extracellular vesicles) and non-exosomal. This nature of miRs not only affects the uptake into target cells but also poses a challenge and opportunity for RNA therapeutics in cancer. By virtue of their ability to act as mediators of intercellular communication in the tumor microenvironment, extracellular m

SUBMITTER: Syed SN 

PROVIDER: S-EPMC9104172 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature