Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity.

ABSTRACT:

Background

Purine isosteres are often endowed with interesting pharmacological properties, due to their involvement in cellular processes replacing the natural purines. Among these compounds, pyrazolopyridines are under active investigation for potential anticancer properties.

Objectives

Based on previously discovered substituted pyrazolopyridines with promising antiproliferative activity, we designed and synthesized new, suitably substituted analogues aiming to investigate their potential activity and contribute to SAR studies of this class of bioactive compounds.

Methods

The new compounds were synthesized using suitably substituted 2-amino-4-picolines, which upon ring-closure provided substituted pyrazolo[3,4-c] pyridine-5-carbonitriles that served as key intermedia

SUBMITTER: Giannouli V 

PROVIDER: S-EPMC9104188 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature